Loratadine

• CAT Number: A000505
• CAS Number: 79794-75-5
• Molecular Formula: C22H23ClN2O2
• Molecular Weight: 382.90
• Purity: 98%
• Synonyms: Claritin; Loratidine; Alavert
• Target: GPCR/G Protein
• Solubility: Soluble in DMSO > 10 mM
• Appearance: Solid powder
• Storage: -20°C
• IUPAC Name: ethyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
• InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
• InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• SMILES: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1

Loratadine（Cat No.:A000505）is a second-generation antihistamine widely used to treat allergic conditions such as hay fever, allergic rhinitis, and urticaria (hives). As a selective H1 receptor antagonist, Loratadine works by blocking the action of histamine, which helps alleviate symptoms like sneezing, runny nose, itchy eyes, and skin rashes. It is known for its non-drowsy formula due to minimal penetration of the blood-brain barrier, making it a popular choice for daytime allergy relief. Loratadine is available in various formulations, including tablets, syrups, and dissolvable tablets for convenient use.

Overview of Clinical Research

Loratadine is a Histamine H1 receptor antagonist developed by the NovaDel Pharma.The Phase-II for Seasonal allergic rhinitis in USA (Transmucosal) was suspended in 2004.

Reference

1: Kay GG, Harris AG. Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation. Clin Exp Allergy. 1999 Jul;29 Suppl 3:147-50. Review. PubMed PMID: 10444229.
2: Monroe EW. Safety and efficacy of loratadine in urticaria. Int J Dermatol. 1996 Dec;35(12):837-41. Review. PubMed PMID: 8970837.
3: Clissold SP, Sorkin EM, Goa KL. Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1989 Jan;37(1):42-57. Review. PubMed PMID: 2523301.