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59729-31-6-Lorcainid Lorcainid

Lorcainid

For research use only. Not for therapeutic Use.

  • CAT Number: I031000
  • CAS Number: 59729-31-6
  • Molecular Formula: C22H27ClN2O
  • Molecular Weight: 370.92
  • Purity: 98%
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Related Small Molecules: ICA 069673     BET-IN-19     Talbutal    

Lorcainid is an anti-arrhythmia agent.


Catalog Number I031000
CAS Number 59729-31-6
Synonyms

Lorcainid; Lorcainide; Lorcainidum;

Molecular Formula C22H27ClN2O
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name N-(4-chlorophenyl)-N-(1-isopropylpiperidin-4-yl)-2-phenylacetamide
InChI InChI=1S/C22H27ClN2O/c1-17(2)24-14-12-21(13-15-24)25(20-10-8-19(23)9-11-20)22(26)16-18-6-4-3-5-7-18/h3-11,17,21H,12-16H2,1-2H3
InChIKey XHOJAWVAWFHGHL-UHFFFAOYSA-N
SMILES O=C(N(C1=CC=C(Cl)C=C1)C2CCN(C(C)C)CC2)CC3=CC=CC=C3
Reference

1: Hampton J. Therapeutic fashion and publication bias: the case of anti-arrhythmic drugs in heart attack. J R Soc Med. 2015 Oct;108(10):418-20. doi: 10.1177/0141076815608562. PubMed PMID: 26459066.
2: Gstöttner M, Ng CK, Gmeiner R. [Lorcainid–electrophysiologic examinations of a new anti-arrhythmia agent]. Acta Med Austriaca. 1978;5(4-5):137-8. German. PubMed PMID: 756123.
3: Del Tredici AL, Ma JN, Piu F, Burstein ES. Identification of the antiarrhythmic drugs amiodarone and lorcainide as potent H3 histamine receptor inverse agonists. J Pharmacol Exp Ther. 2014 Jan;348(1):116-24. doi: 10.1124/jpet.113.208892. Epub 2013 Nov 7. PubMed PMID: 24204014.
4: Chalmers I. The true lorcainide story. BMJ. 2015 Jan 28;350:h287. doi: 10.1136/bmj.h287. PubMed PMID: 25630497.
5: Kersting F, Kasper W, Meinertz T, Just H, Jähnchen E. [Cardiovascular effects of lorcainid, a new anti-arrhythmic substance]. Verh Dtsch Ges Inn Med. 1978;(84):687-9. German. PubMed PMID: 154243.
6: Pond SM, Tozer TN. First-pass elimination. Basic concepts and clinical consequences. Clin Pharmacokinet. 1984 Jan-Feb;9(1):1-25. Review. PubMed PMID: 6362950.
7: Evers J, Büttner-Belz U. Fatal lorcainide poisoning. J Toxicol Clin Toxicol. 1995;33(2):157-9. PubMed PMID: 7897755.
8: Ronfeld RA. Comparative pharmacokinetics of new antiarrhythmic drugs. Am Heart J. 1980 Dec;100(6 Pt 2):978-83. Review. PubMed PMID: 6778195.
9: Hellestrand KJ. Comparison of the efficacy of newly developed antiarrhythmic drugs in the treatment of ventricular tachyarrhythmias. Eur Heart J. 1984 Sep;5 Suppl B:87-94. Review. PubMed PMID: 6437822.
10: Orning OM. The use of tocainide, encainide, lorcainide and flecainide for supraventricular arrhythmias. Eur Heart J. 1984 Sep;5 Suppl B:81-6. PubMed PMID: 6437821.
11: Cowley AJ, Skene A, Stainer K, Hampton JR. The effect of lorcainide on arrhythmias and survival in patients with acute myocardial infarction: an example of publication bias. Int J Cardiol. 1993 Jul 1;40(2):161-6. PubMed PMID: 8349379.
12: Witek A, Przyborowski L. Chromatographic (TLC) analysis of diltiazem in pharmaceutical form in presence of other antiarrhythmics. Acta Pol Pharm. 1996 Jan-Feb;53(1):9-12. PubMed PMID: 8960279.
13: Kelliher GJ, Kowey P, Engel T, Wetstein L. Clinical pharmacology of antiarrhythmic agents. Cardiovasc Clin. 1985;16(1):287-305. Review. PubMed PMID: 2874883.
14: Meinertz T, Kasper W, Stengel E, Waldecker B, Löllgen H, Jähnchen E, Bechtold H, Just J. Comparison of the antiarrhythmic activity of mexiletine and lorcainide on ventricular arrhythmias. Z Kardiol. 1982 Jan;71(1):35-8. PubMed PMID: 7039160.
15: Falk RH, O’Brien JL. Lorcainide. A comparative trial with quinidine gluconate in patients with previously untreated ventricular arrhythmias. Chest. 1984 Oct;86(4):537-40. PubMed PMID: 6383741.
16: Meuldermans W, Hurkmans R, Swysen E, Hendrickx J, Thijssen J, Lauwers W, Heykants J. Excretion and metabolism of lorcainide in rats, dogs and man. Eur J Drug Metab Pharmacokinet. 1983 Oct-Dec;8(4):335-49. PubMed PMID: 6673971.
17: Amery WK, Heykants J, Bruyneel K, Terryn R. Bioavailability and saturation of the presystemic metabolism of oral lorcainide therapy initiated in three different dose regimens. Eur J Clin Pharmacol. 1983;24(4):517-9. PubMed PMID: 6861866.
18: McDevitt DG. The clinical pharmacology of lidocaine congeners–review of encainide, flecainide, lorcainide and tocainide. Eur Heart J. 1984 Sep;5 Suppl B:63-6. PubMed PMID: 6437818.
19: Podrid PJ. Antiarrhythmic drug therapy (Part 2). Benefits and hazards. Chest. 1985 Oct;88(4):618-24. Review. PubMed PMID: 3930162.
20: Gillis AM, Kates RE. Clinical pharmacokinetics of the newer antiarrhythmic agents. Clin Pharmacokinet. 1984 Sep-Oct;9(5):375-403. Review. PubMed PMID: 6437721.

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