For research use only. Not for therapeutic Use.
Lorundrostat（Cat No.:I043405）is a selective inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme involved in the conversion of inactive cortisone to active cortisol. By inhibiting this enzyme, Lorundrostat reduces cortisol levels, which can help manage conditions related to excess cortisol, such as Cushing’s syndrome. This compound is being investigated for its potential in treating metabolic disorders, including obesity, insulin resistance, and hypertension. Clinical studies suggest that Lorundrostat may offer a promising approach to correcting the metabolic imbalances caused by overactive cortisol production.
| CAS Number | 1820940-17-7 |
| Synonyms | N-(4-acetamidocyclohexyl)-2-[4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]piperazin-1-yl]acetamide |
| Molecular Formula | C24H33N7O2 |
| Purity | ≥95% |
| IUPAC Name | N-(4-acetamidocyclohexyl)-2-[4-[5-(4-methylphenyl)-1,2,4-triazin-3-yl]piperazin-1-yl]acetamide |
| InChI | InChI=1S/C24H33N7O2/c1-17-3-5-19(6-4-17)22-15-25-29-24(28-22)31-13-11-30(12-14-31)16-23(33)27-21-9-7-20(8-10-21)26-18(2)32/h3-6,15,20-21H,7-14,16H2,1-2H3,(H,26,32)(H,27,33) |
| InChIKey | YHGVDZULVMINCJ-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=CN=NC(=N2)N3CCN(CC3)CC(=O)NC4CCC(CC4)NC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
