Losartan Carboxylic Acid

• CAT Number: R004266
• CAS Number: 124750-92-1
• Molecular Formula: C22H21ClN6O2
• Molecular Weight: 436.9
• Purity: ≥95%
• Synonyms: 2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid; EXP 3174
• Target: Angiotensin Receptor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
• InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
• InChIKey: ZEUXAIYYDDCIRX-UHFFFAOYSA-N
• SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)Cl

Losartan carboxylic acid is a metabolite of losartan, an angiotensin II receptor blocker (ARB) commonly used to treat hypertension and protect the kidneys in people with type 2 diabetes. This carboxylic acid derivative is formed through the oxidation of the tetrazole ring in losartan, leading to its active form, which has a longer half-life and contributes significantly to the drug’s therapeutic effects. Losartan carboxylic acid retains the ability to block the angiotensin II receptor, helping to lower blood pressure and reduce the risk of cardiovascular events. It is often studied in pharmacokinetic and pharmacodynamic research to understand the metabolism and efficacy of losartan.