For research use only. Not for therapeutic Use.
Losartan(Cat No.:I000549)is an angiotensin II receptor antagonist that effectively competes with angiotensin II for binding to AT1 receptors, displaying an IC50 value of 20 nM. By binding to AT1 receptors, losartan blocks the effects of angiotensin II, a hormone responsible for vasoconstriction and the release of aldosterone. This results in the relaxation of blood vessels, reduced blood pressure, and decreased aldosterone secretion. Losartan is commonly prescribed for the management of hypertension and may also be used to treat certain kidney conditions.
Catalog Number | I000549 |
CAS Number | 114798-26-4 |
Synonyms | [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
Molecular Formula | C22H23ClN6O |
Purity | ≥95% |
Target | Angiotensin Receptor |
Solubility | 10 mM in DMSO |
Storage | 2-8°C |
IC50 | 20 nM |
IUPAC Name | [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol |
InChI | InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) |
InChIKey | PSIFNNKUMBGKDQ-UHFFFAOYSA-N |
SMILES | CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl |
Reference | <p style=/line-height:25px/> |