Losartan potassium

• CAT Number: A000511
• CAS Number: 124750-99-8
• Molecular Formula: C₂₂H₂₂ClKN₆O
• Molecular Weight: 461
• Purity: ≥95%
• Synonyms: MK 954; 124750-99-8; Cozaar; Lorzaar; Losaprex; Hyzaar
• Target: Angiotensin Receptor
• Solubility: >21.4mg/mL in DMSO
• Storage: -20°C
• InChI: InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• InChIKey: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

Losartan Potassium is a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.

Reference

1: Hong SJ, Jeong HS, Han SH, Chang KY, Hong BK, Lee BK, Chae SC, Kim WS, Park
CG, Heo JH, Lee SU, Kim YD, Kim KS, Choi JH, Kang HJ, Kim JJ, Kang SM, Choi YJ,
Shin JH, Chun KJ, Shin DG, Park SH, Kwan J, Choi YJ, Jeong MH, Chae JK, Kim DW,
Cho JR, Han KR, Won KH, Park SH, Lee SK, Kim SH, Jung J, Kim CH. Comparison of
Fixed-dose Combinations of Amlodipine/Losartan Potassium/Chlorthalidone and
Amlodipine/Losartan Potassium in Patients With Stage 2 Hypertension Inadequately
Controlled With Amlodipine/Losartan Potassium: A Randomized, Double-blind,
Multicenter, Phase III Study. Clin Ther. 2017 Oct;39(10):2049-2060. doi:
10.1016/j.clinthera.2017.08.013. Epub 2017 Sep 19. PubMed PMID: 28939406.

2: Li P, Chen YZ, Lin HL, Ni ZH, Zhan YL, Wang R, Yang HT, Fang JA, Wang NS, Li
WG, Sun XF, Chen XM. Abelmoschus manihot – a traditional Chinese medicine versus
losartan potassium for treating IgA nephropathy: study protocol for a randomized
controlled trial. Trials. 2017 Apr 11;18(1):170. doi: 10.1186/s13063-016-1774-6.
PubMed PMID: 28395659; PubMed Central PMCID: PMC5387231.

3: Lima MJ, Reis BF. A clean photometric method for the determination of losartan
potassium in pharmaceuticals exploiting light scattering effect and employing a
multicommuted flow analysis approach. Talanta. 2017 Mar 1;164:183-188. doi:
10.1016/j.talanta.2016.11.011. Epub 2016 Nov 9. PubMed PMID: 28107915.

4: Handa T, Jhajra S, Bhagat S, Bharatam PV, Chakraborti AK, Singh S. Molecular
insight into atypical instability behavior of fixed-dose combination containing
amlodipine besylate and losartan potassium. J Pharm Biomed Anal. 2017 Mar
20;136:66-80. doi: 10.1016/j.jpba.2016.12.035. Epub 2016 Dec 29. PubMed PMID:
28064090.

5: Silva-Oliveira RG, Orsolin PC, Nepomuceno JC. Modulating effect of losartan
potassium on the mutagenicity and recombinogenicity of doxorubicin in somatic
cells of Drosophila melanogaster. Food Chem Toxicol. 2016 Sep;95:211-8. doi:
10.1016/j.fct.2016.07.003. Epub 2016 Jul 7. PubMed PMID: 27394655.

6: Li L, Lai C, Xuan X, Gao C, Li N. Simultaneous Determination of
Hydrochlorothiazide and Losartan Potassium in Osmotic Pump Tablets by
Microemulsion Liquid Chromatography. J Chromatogr Sci. 2016 Sep;54(8):1415-20.
doi: 10.1093/chromsci/bmw101. Epub 2016 Jun 21. PubMed PMID: 27334292.

7: Ikram M, Gilhotra N, Gilhotra RM. Formulation and optimization of mucoadhesive
buccal patches of losartan potassium by using response surface methodology. Adv
Biomed Res. 2015 Oct 29;4:239. doi: 10.4103/2277-9175.168606. eCollection 2015.
PubMed PMID: 26682205; PubMed Central PMCID: PMC4673708.

8: Khan KA, Khan GM, Zeeshan Danish M, Akhlaq, Khan H, Rehman F, Mehsud S.
Formulation and in-vitro evaluation of directly compressed controlled release
matrices of Losartan Potassium using Ethocel Grade 100 as rate retarding agent.
Int J Pharm. 2015 Dec 30;496(2):759-65. doi: 10.1016/j.ijpharm.2015.10.051. Epub
2015 Nov 3. PubMed PMID: 26545310.

9: Das AK, Dhanure S, Savalia AK, Nayak SK, Tripathy SK. Human bioequivalence
evaluation of two losartan potassium tablets under fasting conditions. Indian J
Pharm Sci. 2015 Mar-Apr;77(2):190-5. PubMed PMID: 26009652; PubMed Central PMCID:
PMC4442468.

10: Godoy AA, Kummrow F, Pamplin PA. Ecotoxicological evaluation of propranolol
hydrochloride and losartan potassium to Lemna minor L. (1753) individually and in
binary mixtures. Ecotoxicology. 2015 Jul;24(5):1112-23. doi:
10.1007/s10646-015-1455-3. Epub 2015 Apr 7. PubMed PMID: 25847105.