Lotilaner

• CAT Number: I007711
• CAS Number: 1369852-71-0
• Molecular Formula: C20H14Cl3F6N3O3S
• Molecular Weight: 596.75
• Purity: 98%
• Synonyms: Lotilaner;(S)-3-methyl-N-(2-oxo-2-((2,2,2-trifluoroethyl)amino)ethyl)-5-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)thiophene-2-carboxamide
• Target: γ- GABACl
• Target Protein: E0W492
• Solubility: Soluble in DMSO, not in water
• Appearance: Solid
• Storage: Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
• IC50: IC50: 23.84 nM (DmS-GABA)
• IUPAC Name: 3-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]thiophene-2-carboxamide
• InChI: InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
• InChIKey: HDKWFBCPLKNOCK-SFHVURJKSA-N
• SMILES: CC1=C(SC(=C1)C2=NO[C@@](C2)(C3=CC(=C(C(=C3)Cl)Cl)Cl)C(F)(F)F)C(=O)NCC(=O)NCC(F)(F)F

Lotilaner（Cat No.:I007711）is an oral ectoparasiticide belonging to the isoxazoline class, primarily used for the treatment of flea and tick infestations in animals. It works by selectively inhibiting the gamma-aminobutyric acid (GABA)-gated chloride channels in the nervous system of parasites, causing paralysis and death. Lotilaner is effective against a wide range of ectoparasites, offering long-lasting protection with a rapid onset of action. Its safety profile and ease of administration make it a popular choice for veterinarians, providing an efficient and reliable solution for controlling fleas and ticks in pets.