For research use only. Not for therapeutic Use.
Loxapine (Cat.No:I000025) is an antipsychotic medication used in the treatment of schizophrenia. It works by blocking certain receptors in the brain to help restore the balance of neurotransmitters. Loxapine is also sometimes prescribed for the management of bipolar disorder and other psychiatric conditions. It is available in various forms, including oral tablets and inhalation powder.
| Catalog Number | I000025 |
| CAS Number | 1977-10-2 |
| Synonyms | 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine |
| Molecular Formula | C18H18ClN3O |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| Reference | </br>1:Pharmacokinetics and Safety of Single-Dose Inhaled Loxapine in Children and Adolescents. Selim S, Riesenberg R, Cassella J, Kunta J, Hellriegel E, Smith MA, Vinks AA, Rabinovich-Guilatt L.J Clin Pharmacol. 2017 May 16. doi: 10.1002/jcph.932. [Epub ahead of print] PMID: 28510296 </br>2:Rationale and design of the PLACID study: a randomised trial comparing the efficacy and safety of inhaled loxapine versus IM aripiprazole in acutely agitated patients with schizophrenia or bipolar disorder. San L, Estrada G, Oudovenko N, Vieta E.BMC Psychiatry. 2017 Apr 4;17(1):126. doi: 10.1186/s12888-017-1291-5. PMID: 28376877 Free PMC Article</br>3:Dopamine antagonists for treatment resistance in autism spectrum disorders: review and focus on BDNF stimulators loxapine and amitriptyline. Hellings JA, Arnold LE, Han JC.Expert Opin Pharmacother. 2017 Apr;18(6):581-588. doi: 10.1080/14656566.2017.1308483. Review. PMID: 28335658 </br>4:The Role of Inhaled Loxapine in the Treatment of Acute Agitation in Patients with Psychiatric Disorders: A Clinical Review. de Berardis D, Fornaro M, Orsolini L, Iasevoli F, Tomasetti C, de Bartolomeis A, Serroni N, Valchera A, Carano A, Vellante F, Marini S, Piersanti M, Perna G, Martinotti G, Di Giannantonio M.Int J Mol Sci. 2017 Feb 8;18(2). pii: E349. doi: 10.3390/ijms18020349. Review. PMID: 28208695 Free PMC Article</br>5:Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents. Dong M, Fukuda T, Selim S, Smith MA, Rabinovich-Guilatt L, Cassella JV, Vinks AA.Clin Pharmacokinet. 2017 Feb 15. doi: 10.1007/s40262-017-0512-x. [Epub ahead of print] PMID: 28205038 </br>6:ClinicalTrials.gov, Inhaled Loxapine, and Safety Issues. Shader RI.J Clin Psychopharmacol. 2017 Apr;37(2):119-121. doi: 10.1097/JCP.0000000000000679. No abstract available. PMID: 28187007 </br>7:Simultaneous quantification of loxapine, loxapine N-oxide, amoxapine, 8-hydroxyloxapine and 7-hydroxyloxapine in human plasma using LC-MS/MS. Meng M, Zhao N, Pederson CC, Harrison E, Green C, Gorman SH, Reuschel S.J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Mar 1;1046:87-97. doi: 10.1016/j.jchromb.2017.01.007. Epub 2017 Jan 9. PMID: 28152454 </br>8:Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response. Aboueid L, McCarthy RH.Case Rep Psychiatry. 2016;2016:6123913. doi: 10.1155/2016/6123913. Epub 2016 Jun 28. PMID: 27433365 Free PMC Article</br>9:Inhaled loxapine for the urgent treatment of acute agitation associated with schizophrenia or bipolar disorder. Pollack CV Jr.Curr Med Res Opin. 2016 Jul;32(7):1253-60. doi: 10.1185/03007995.2016.1170004. Epub 2016 Jun 1. PMID: 27121764 </br>10:Inhaled loxapine and intramuscular lorazepam in healthy volunteers: a randomized placebo-controlled drug-drug interaction study. Spyker DA, Cassella JV, Stoltz RR, Yeung PP.Pharmacol Res Perspect. 2015 Dec 17;3(6):e00194. doi: 10.1002/prp2.194. eCollection 2015 Dec. PMID: 27022468 Free PMC Article |
