Loxapine Succinate

For research use only. Not for therapeutic Use.

  • CAT Number: A000797
  • CAS Number: 27833-64-3
  • Molecular Formula: C22H24ClN3O5
  • Molecular Weight: 445.9
  • Purity: ≥95%
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Loxapine Succinate is a D2DR and D4DR inhibitor and serotonergic receptor antagonist. Loxapine succinate is an antipsychotic agent used in schizophrenia.


Catalog Number A000797
CAS Number 27833-64-3
Synonyms

27833-64-3; Loxapine succinate salt; Loxapac; Daxolin; Lederle

Molecular Formula C22H24ClN3O5
Purity ≥95%
Target Neuronal Signaling
Storage -20°C
InChI 1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChIKey YQZBAXDVDZTKEQ-UHFFFAOYSA-N
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.C(CC(=O)O)C(=O)O
Reference

1: Bhardwaj RM, Johnston BF, Oswald ID, Florence AJ. A complementary experimental
and computational study of loxapine succinate and its monohydrate. Acta
Crystallogr C. 2013 Nov;69(Pt 11):1273-8. doi: 10.1107/S0108270113029363. Epub
2013 Oct 31. PubMed PMID: 24192171.
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2: Escande M, Granier F, Gardes JP, Boscredon J, Concina M. [Clinical trial of
loxapine succinate in the treatment of 30 cases of psychotic states]. Ann Med
Psychol (Paris). 1983 Mar;141(3):309-22. French. PubMed PMID: 6357022.
<br>

3: Feldman HS. Loxapine succinate as initial treatment of hostile and aggressive
schizophrenic criminal offenders. J Clin Pharmacol. 1982 Aug-Sep;22(8-9):366-70.
PubMed PMID: 7130427.

<br>
4: James B, McIntyre M, Hannah J. A study of parenteral loxapine succinate in
very disturbed psychotic patients. N Z Med J. 1982 Feb 24;95(702):123-4. PubMed
PMID: 6952119.

<br>
5: Zisook S, Click MA Jr. Evaluations of loxapine succinate in the ambulatory
treatment of acute schizophrenic episodes. Int Pharmacopsychiatry.
1980;15(6):365-78. Review. PubMed PMID: 7028656.

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6: Cottereau MJ, Poirier MF, L&#244;o H, Deniker P. [Loxapine succinate: a new
neuroleptic]. Encephale. 1979;5(3):251-67. French. PubMed PMID: 39739.
<br>

7: Branchey MH, Lee JH, Simpson GM, Elgart B, Vicencio A. Loxapine succinate as a
neuroleptic agent: evaluation in two populations of elderly psychiatric patients.
J Am Geriatr Soc. 1978 Jun;26(6):263-7. PubMed PMID: 757995.
<br>

8: Clark ML, Paredes A, Costiloe JP, Fulkerson FG, Wood F. Evaluation of two dose
levels of loxapine succinate in chronic schizophrenia. Dis Nerv Syst. 1977
Jan;38(1):7-10. PubMed PMID: 318984.
<br>

9: Chouinard G, Annable L, DeMontigny C, Kropsky ML. Loxapine succinate in the
treatment of newly admitted schizophrenic patients. Curr Ther Res Clin Exp. 1977
Jan;21(1):73-9. PubMed PMID: 12921.

<br>
10: Nair NP, Decker BL, Schwartz G. Loxapine succinate in the treatment of
chronic schizophrenia. Curr Ther Res Clin Exp. 1976 Dec;20(6):802-9. PubMed PMID:
12919.

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