For research use only. Not for therapeutic Use.
LP-471756 is a potent GPR139 antagonist with an IC50 value of 640 nM. LP-471756 inhibits LP-360924-stimulated cAMP production[1][2].
LP-471756 (0-1000 µM) inhibits specifically LP-360924-stimulated cAMP production in GPR139 cells with an IC50 value of 0.64 µM[2].
| Catalog Number | I007716 |
| CAS Number | 413605-11-5 |
| Synonyms | 4-cyclohexyl-N-(2-methylphenyl)benzenesulfonamide |
| Molecular Formula | C19H23NO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23NO2S/c1-15-7-5-6-10-19(15)20-23(21,22)18-13-11-17(12-14-18)16-8-3-2-4-9-16/h5-7,10-14,16,20H,2-4,8-9H2,1H3 |
| InChIKey | STLMNZVBCJVQOZ-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1NS(=O)(=O)C2=CC=C(C=C2)C3CCCCC3 |
| Reference | [1]. Vedel L, et al. Pharmacology and function of the orphan GPR139 G protein-coupled receptor. Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. [2]. Hu LA, et al. Identification of surrogate agonists and antagonists for orphan G-protein-coupled receptor GPR139. J Biomol Screen. 2009 Aug;14(7):789-97. |
