For research use only. Not for therapeutic Use.
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase.<br>LRE1 binds to the bicarbonate activator binding site and inhibits soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1].
LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition[1].
LRE1 (0.5-100 μM, 60 minutes ) inhibits sperm and mitochondrial functions of sAC[1].
| Catalog Number | I019647 |
| CAS Number | 1252362-53-0 |
| Molecular Formula | C₁₂H₁₃ClN₄S |
| Purity | ≥95% |
| Target | Adenylate Cyclase |
| Reference | [1]. Ramos-Espiritu L, et al. Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase. Nat Chem Biol. 2016 Oct;12(10):838-44. |
