LSD1-IN-24

• CAT Number: I041746
• CAS Number: 4734-59-2
• Molecular Formula: C18H20N2OS
• Molecular Weight: 312.43
• Purity: ≥95%
• Synonyms: 4-(2-phenothiazin-10-ylethyl)morpholine
• InChI: InChI=1S/C18H20N2OS/c1-3-7-17-15(5-1)20(10-9-19-11-13-21-14-12-19)16-6-2-4-8-18(16)22-17/h1-8H,9-14H2
• InChIKey: VJQXIWLVJMDRGV-UHFFFAOYSA-N
• SMILES: C1COCCN1CCN2C3=CC=CC=C3SC4=CC=CC=C42

LSD1-IN-24(compound 3S) is a selective LSD1 inhibitor with IC50 = 0.247 μM. LSD1-IN-24 can mediate the expression of PD-L1, enhance T cell killing response, and can be used in cancer research[1].
LSD1-IN-24 (compound 3S)(0-20 μM, 5 days) can reduce PD-L1 levels in an LSD1-dependent manner and enhance the T cell killing response of BGC-823 cells in a dose-dependent manner, but does not affect BGC -823 and MFC cell proliferation. Furthermore, it dose-dependently protects H3K4me1/2 but not H3K4me3 from demethylation[1].
LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) inhibits in vivo MFC cell growth, tumor weight in a dose-dependent manner in a subcutaneous tumor model containing MFC cells Significantly decreased, tumor tissue Ki67 decreased significantly, and no obvious toxic effect on mice[1].

Reference

[1]. Xing-Jie Dai, et al. Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells. J Med Chem. 2023 Mar 23;66(6):3896-3916. 
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