For research use only. Not for therapeutic Use.
LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model[1]. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Catalog Number | R014433 |
| CAS Number | 1401031-52-4 |
| Synonyms | N-propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide |
| Molecular Formula | C16H15N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C16H15N3O/c1-12(2)19-16(20)15-6-5-14(11-18-15)4-3-13-7-9-17-10-8-13/h5-12H,1-2H3,(H,19,20) |
| InChIKey | STAFRSGTRKNXHF-UHFFFAOYSA-N |
| SMILES | CC(C)NC(=O)C1=NC=C(C=C1)C#CC2=CC=NC=C2 |
| Reference | [1]. Gastambide F, et al. The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat. Neuropharmacology. 2013;64:240-247. |
