LtaS-IN-1

• CAT Number: I016826
• CAS Number: 877950-01-1
• Molecular Formula: C₂₄H₁₇N₃O₅
• Molecular Weight: 427.41
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] 2-benzo[e][1]benzofuran-1-ylacetate
• InChI: InChI=1S/C24H17N3O5/c28-20(25-24-27-26-23(32-24)16-7-2-1-3-8-16)14-31-21(29)12-17-13-30-19-11-10-15-6-4-5-9-18(15)22(17)19/h1-11,13H,12,14H2,(H,25,27,28)
• InChIKey: KNJXREYSQNBQEX-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)C2=NN=C(O2)NC(=O)COC(=O)CC3=COC4=C3C5=CC=CC=C5C=C4

LtaS-IN-1（Cat No.:I016826）is a selective inhibitor of the LtaS (lipoteichoic acid synthase) enzyme, which plays a crucial role in the biosynthesis of lipoteichoic acid (LTA) in Gram-positive bacteria. By targeting LtaS, LtaS-IN-1 disrupts bacterial cell wall integrity, rendering the bacteria more susceptible to immune responses and antibiotics. This compound holds potential as an antibacterial agent, particularly for combating infections caused by drug-resistant Gram-positive pathogens such as Staphylococcus aureus and Streptococcus pneumoniae. LtaS-IN-1 offers a promising approach to novel antimicrobial therapy and bacterial resistance management.

Reference

[1]. Paganelli FL, et al. Lipoteichoic acid synthesis inhibition in combination with antibiotics abrogates growth of multidrug-resistant Enterococcus faecium.Int J Antimicrob Agents. 2017 Mar;49(3):355-363.