For research use only. Not for therapeutic Use.
LTGO-33 is a potent and selective inhibitor of voltage-gated sodium channel NaV1.8. LTGO-33, with its potency in the nanomolar range, selectively inhibits NaV1.8 over 600 times more than human NaV1.1-NaV1.7 and NaV1.9. Its inhibition is not dependent on the state of the channels and displays consistent potency against both closed and inactivated conformations. LTGO-33 holds promise for research in pain disorders.
| Catalog Number | I047338 |
| CAS Number | 2834106-06-6 |
| Molecular Formula | C21H17F4N3O3S |
| Purity | ≥95% |
| Reference | [1] Gilchrist JM, et al. Mol Pharmacol. 2024 Feb 15;105(3):233-249. |
