LTI-291

• CAT Number: I012951
• CAS Number: 1919820-28-2
• Molecular Formula: C₂₀H₃₀N₄O₂
• Molecular Weight: 358.48
• Purity: ≥95%
• Target: Glucosidase
• Solubility: DMSO
• IUPAC Name: 5,7-dimethyl-N-(4-pentoxycyclohexyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• InChI: InChI=1S/C20H30N4O2/c1-4-5-6-11-26-17-9-7-16(8-10-17)23-20(25)18-13-21-24-15(3)12-14(2)22-19(18)24/h12-13,16-17H,4-11H2,1-3H3,(H,23,25)
• InChIKey: HZILSILAELSWKN-UHFFFAOYSA-N
• SMILES: CCCCCOC1CCC(CC1)NC(=O)C2=C3N=C(C=C(N3N=C2)C)C

LTI-291 (CAT: I012951) is a compound that acts as an activator of glucocerebrosidase (Gcase). Glucocerebrosidase is an enzyme involved in the breakdown of glucocerebroside, a lipid molecule that accumulates in cells in certain lysosomal storage disorders, such as Gaucher disease. LTI-291 has shown potential as a therapeutic agent for increasing the activity of glucocerebrosidase, thereby promoting the clearance of glucocerebroside and reducing its accumulation in affected cells. This activation of Gcase may provide a promising approach for the treatment of lysosomal storage disorders associated with glucocerebroside buildup.

Reference

[1]. Renato T. Skerlj, et al. Methods of treatment and combination therapies using gcase activator heterobicyclic and related compounds. WO 2017192841 A1.