LTURM 34

• CAT Number: I011314
• CAS Number: 1879887-96-3
• Molecular Formula: C24H18N2O3S
• Molecular Weight: 414.48
• Purity: ≥95%
• Synonyms: 8-(4-Dibenzothienyll)-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one
• Target: PI3K/Akt/mTOR
• Solubility: Soluble to 50 mM in DMSO
• Storage: Store at +4C

LTURM 34(CAT: I011314) is a potent inhibitor of DNA-dependent protein kinase (DNA-PK) with an impressive inhibitory concentration (IC50) of 34 nanomolar. Notably, LTURM 34 demonstrates a remarkable selectivity towards DNA-PK over phosphoinositide 3-kinase (PI3-K) with a selectivity ratio of 170-fold. This compound’s ability to target and inhibit DNA-PK highlights its potential in interfering with DNA repair processes and cellular signaling pathways. Its inhibitory effects have been observed to attenuate the proliferation of various tumor cell lines in vitro.