For research use only. Not for therapeutic Use.
Lubiprostone is an activator of ClC-2 chloride channels, used in the management of idiopathic chronic constipation.<br>Lubiprostone induces a robust secretory response in T84 monolayers. Lubiprostone induces a rise in cAMP levels that was sensitive to EP(4)-receptor blockage in T84 cells.<br>Lubiprostone induces a CdCl(2)-insensitive secretory response in mouse intestine, but fail to induce intestinal Cl(-) secretion in Cftr-null mice.
| Catalog Number | A000745 |
| CAS Number | 136790-76-6 |
| Synonyms | RU 0211 |
| Molecular Formula | C20H32F2O5 |
| Purity | ≥95% |
| Target | ClC-2 chloride channels |
| Storage | 3 years -20C powder |
