For research use only. Not for therapeutic Use.
lucPpy-IN-1 (compound 9) is an ATP-dependent luciferase from Photinus pyralis (lucPpy) inhibitor with an IC50 value of 4.0 μM. lucPpy-IN-1 can be used for the research of target’s agentgability[1].
lucPpy-IN-1 (0.1 nM-100 µM) inhibits activity of lucPpy with an IC50 value of 4.0 µM[1].
| Catalog Number | I042487 |
| CAS Number | 546100-66-7 |
| Synonyms | [2-(4-methylphenyl)quinolin-4-yl]-(4-pyrimidin-2-ylpiperazin-1-yl)methanone |
| Molecular Formula | C25H23N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C25H23N5O/c1-18-7-9-19(10-8-18)23-17-21(20-5-2-3-6-22(20)28-23)24(31)29-13-15-30(16-14-29)25-26-11-4-12-27-25/h2-12,17H,13-16H2,1H3 |
| InChIKey | BESCHBVTVJFEFE-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)N4CCN(CC4)C5=NC=CC=N5 |
| Reference | [1]. Auld DS, et al. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem. 2009 Mar 12;52(5):1450-8. |
