LUF5771

• CAT Number: I031105
• CAS Number: 1141802-49-4
• Molecular Formula: C24H23NO
• Molecular Weight: 357.45
• Purity: 98%
• Synonyms: LUF5771; LUF 5771; LUF-5771
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (3,5-diphenylphenyl) N-cyclopentylcarbamate
• InChI: InChI=1S/C24H23NO2/c26-24(25-22-13-7-8-14-22)27-23-16-20(18-9-3-1-4-10-18)15-21(17-23)19-11-5-2-6-12-19/h1-6,9-12,15-17,22H,7-8,13-14H2,(H,25,26)
• InChIKey: YNYOWRRXJIPCGX-UHFFFAOYSA-N
• SMILES: C1CCC(C1)NC(=O)OC2=CC(=CC(=C2)C3=CC=CC=C3)C4=CC=CC=C4

LUF5771(Cat No.:I031105) represents a significant advancement in the field of hormone receptor modulation. This compound serves as an allosteric inhibitor of the luteinizing hormone receptor, a key player in reproductive and endocrine signaling. By exerting its inhibitory effect through allosteric mechanisms, LUF5771 disrupts the normal receptor function and may offer therapeutic potential in conditions related to hormone dysregulation. As a selective and targeted intervention, LUF5771 contributes to the broader understanding of hormone receptor signaling and holds promise for the development of novel treatments for hormonal disorders and related pathologies.

Reference

1: Luo QL, Tan JP, Li ZF, Nan WH, Xiao DR. Suzuki-Miyaura coupling of aryl iodides, bromides, and chlorides catalyzed by bis(thiazole) pincer palladium complexes. J Org Chem. 2012 Sep 21;77(18):8332-7. Epub 2012 Sep 7. PubMed PMID: 22928706.
2: Heitman LH, Kleinau G, Brussee J, Krause G, Ijzerman AP. Determination of different putative allosteric binding pockets at the lutropin receptor by using diverse drug-like low molecular weight ligands. Mol Cell Endocrinol. 2012 Apr 4;351(2):326-36. doi: 10.1016/j.mce.2012.01.010. Epub 2012 Jan 18. PubMed PMID: 22269095.
3: Heitman LH, Narlawar R, de Vries H, Willemsen MN, Wolfram D, Brussee J, Ijzerman AP. Substituted terphenyl compounds as the first class of low molecular weight allosteric inhibitors of the luteinizing hormone receptor. J Med Chem. 2009 Apr 9;52(7):2036-42. doi: 10.1021/jm801561h. Erratum in: J Med Chem. 2010 Jan 14;53(1):520. PubMed PMID: 19296599.