Lumateperone PTSA salt

• CAT Number: I007735
• CAS Number: 1187020-80-9 (PTSA salt); 313368-91-1 (free base).
• Molecular Formula: C31H36FN3O4S
• Molecular Weight: 565.70
• Purity: ≥95%
• Synonyms: ITI-722; ITI722; ITI 722; ITI-007; ITI007; ITI 007; Lumateperone, CAS#313368-91-1;1-(4-fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3/’,4/’:4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]butan-1-one toluenesulfonic acid
• Target: 5HT2A antagonist
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 1-(4-fluorophenyl)-4-(4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-trien-12-yl)butan-1-one;4-methylbenzenesulfonic acid
• InChI: InChI=1S/C24H28FN3O.C7H8O3S/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17;1-6-2-4-7(5-3-6)11(8,9)10/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3;2-5H,1H3,(H,8,9,10)
• InChIKey: LHAPOGAFBLSJJQ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCN2C3CCN(CC3C4=C2C1=CC=C4)CCCC(=O)C5=CC=C(C=C5)F

Lumateperone PTSA salt(CAT: I007735) is the p-toluenesulfonic acid (PTSA) salt form of Lumateperone, an atypical antipsychotic primarily acting as a serotonin 5-HT2A receptor antagonist and a dopamine D2 receptor modulator. Additionally, it influences glutamatergic neurotransmission by indirectly modulating NMDA receptor activity. This multimodal mechanism contributes to its antipsychotic, antidepressant, and mood-stabilizing effects. Lumateperone PTSA salt is extensively studied in the treatment of schizophrenia, bipolar depression, and other neuropsychiatric disorders. Its balanced receptor activity profile offers enhanced efficacy with reduced side effects, making it a valuable compound in neuroscience and psychiatric drug research.