Lurasidone-d8 Hydrochloride

• CAT Number: R049524
• CAS Number: NA
• Molecular Formula: C₂₈H₂₉D₈ClN₄O₂S
• Molecular Weight: 537.19
• Purity: ≥95%
• Synonyms: (3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione-d8 Hydrochloride; Latuda-d8; SM 13496-d8
• Storage: -20°C
• IUPAC Name: 4-[[(1R,2R)-2-[[4-(1,2-benzothiazol-3-yl)-2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl]methyl]cyclohexyl]methyl]-4-azatricyclo[5.2.1.02,6]decane-3,5-dione;hydrochloride
• InChI: InChI=1S/C28H36N4O2S.ClH/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26;/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2;1H/t18?,19?,20-,21-,24?,25?;/m0./s1/i11D2,12D2,13D2,14D2
• InChIKey: NEKCRUIRPWNMLK-UBKNWVMHSA-N
• SMILES: [2H]C1(C(N(C(C(N1C[C@@H]2CCCC[C@H]2CN3C(=O)C4C5CCC(C5)C4C3=O)([2H])[2H])([2H])[2H])C6=NSC7=CC=CC=C76)([2H])[2H])[2H].Cl

Lurasidone-d8 Hydrochloride is a deuterated form of lurasidone hydrochloride, an atypical antipsychotic used primarily for treating schizophrenia and bipolar disorder. The eight deuterium atoms enhance the compound’s utility in pharmacokinetic and metabolic studies by providing distinct, traceable markers in biological systems. This isotopically labeled version aids researchers in analyzing drug absorption, distribution, metabolism, and excretion (ADME) processes through techniques such as NMR spectroscopy and mass spectrometry. Lurasidone-d8 Hydrochloride is essential in developing a deeper understanding of the drug’s pharmacodynamics, optimizing therapeutic strategies, and ensuring safety and efficacy in clinical applications.