Lurbinectedin-d3

• CAT Number: S000409
• Molecular Formula: C41H41D3N4O10S
• Molecular Weight: 787.89
• Purity: ≥95%
• IUPAC Name: [(1R,2R,3R,11S,12S,14R,26R)-5,12-dihydroxy-6-methoxy-7,21,30-trimethyl-27-oxo-6'-(trideuteriomethoxy)spiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-22-yl] acetate
• InChI: InChI=1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1/i5D3
• InChIKey: YDDMIZRDDREKEP-JKBMFYPJSA-N
• SMILES: CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=C(CCN8)C2=C(N9)C=CC(=C2)OC)OCO7)C)OC(=O)C)C(=C1OC)O

Lurbinectedin-d3（Cat No.:S000409） is a deuterated version of lurbinectedin, where three hydrogen atoms are replaced with deuterium. This modification enhances the stability of the molecule, making it especially useful for pharmacokinetic and metabolic studies. Lurbinectedin is an anticancer medication that works by binding to DNA and interfering with transcription processes in cancer cells, leading to cell death. It is used primarily in the treatment of small-cell lung cancer. The deuterated form, Lurbinectedin-d3, helps researchers to more accurately track and understand the drug’s metabolism, distribution, and excretion in the body, potentially improving therapeutic outcomes.