Luteolin

• CAT Number: I003729
• CAS Number: 491-70-3
• Molecular Formula: C15H10O6
• Molecular Weight: 286.2
• Purity: ≥95%
• Synonyms: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
• Target: IκB/IKK
• Solubility: DMSO: 35 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
• InChIKey: IQPNAANSBPBGFQ-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O

Luteolin (CAT: I003729) is a flavonoid compound widely found in various plants, including fruits, vegetables, and medicinal herbs. It exhibits multiple pharmacological activities, including anti-inflammatory, antioxidant, anticancer, and neuroprotective properties. Luteolin exerts its effects through various mechanisms, such as inhibition of inflammatory mediators, modulation of cellular signaling pathways, and induction of apoptosis in cancer cells. It has been studied for its potential therapeutic applications in various diseases, including cancer, cardiovascular diseases, neurodegenerative disorders, and inflammatory conditions.

Reference

1: Luo Y, Shang P, Li D. Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms. Front Pharmacol. 2017 Oct 6;8:692. doi: 10.3389/fphar.2017.00692. eCollection 2017. Review. PubMed PMID: 29056912; PubMed Central PMCID: PMC5635727.
2: Tuorkey MJ. Molecular targets of luteolin in cancer. Eur J Cancer Prev. 2016 Jan;25(1):65-76. doi: 10.1097/CEJ.0000000000000128. Review. PubMed PMID: 25714651; PubMed Central PMCID: PMC4885545.
3: Lin Y, Shi R, Wang X, Shen HM. Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets. 2008 Nov;8(7):634-46. Review. PubMed PMID: 18991571; PubMed Central PMCID: PMC2615542.
4: Theoharides TC, Kempuraj D, Iliopoulou BP. Mast cells, T cells, and inhibition by luteolin: implications for the pathogenesis and treatment of multiple sclerosis. Adv Exp Med Biol. 2007;601:423-30. Review. PubMed PMID: 17713031.