Lutetium Lu 177 vipivotide tetraxetan

• CAT Number: I048031
• CAS Number: 1703749-62-5
• Molecular Formula: C49H68LuN9O16
• Molecular Weight: 1216.1
• Purity: 98%
• Synonyms: 177Lu-Psma-617; G6UF363ECX; Vipivotide tetraxetan Lu-177; 177Lu-Labeled PSMA-617
• Target: Glutamate carboxypeptidase II (GCPII)
• Target Protein: Q04609
• Appearance: Solid
• IUPAC Name: 2-[4-[2-[[4-[[(2S)-1-[[(5S)-5-carboxy-5-[[(1S)-1,3-dicarboxypropyl]carbamoylamino]pentyl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamoyl]cyclohexyl]methylamino]-2-oxoethyl]-7,10-bis(carboxylatomethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;lutetium-177(3+)
• InChI: InChI=1S/C49H71N9O16.Lu/c59-40(28-55-17-19-56(29-42(62)63)21-23-58(31-44(66)67)24-22-57(20-18-55)30-43(64)65)51-27-32-8-12-35(13-9-32)45(68)52-39(26-33-10-11-34-5-1-2-6-36(34)25-33)46(69)50-16-4-3-7-37(47(70)71)53-49(74)54-38(48(72)73)14-15-41(60)61;/h1-2,5-6,10-11,25,32,35,37-39H,3-4,7-9,12-24,26-31H2,(H,50,69)(H,51,59)(H,52,68)(H,60,61)(H,62,63)(H,64,65)(H,66,67)(H,70,71)(H,72,73)(H2,53,54,74);/q;+3/p-3/t32?,35?,37-,38-,39-;/m0./s1/i;1+2
• InChIKey: RSTDSVVLNYFDHY-IOCOTODDSA-K
• SMILES: C1CC(CCC1CNC(=O)CN2CCN(CCN(CCN(CC2)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])C(=O)NC(CC3=CC4=CC=CC=C4C=C3)C(=O)NCCCCC(C(=O)O)NC(=O)NC(CCC(=O)O)C(=O)O.[Lu+3]

Lutetium Lu 177 vipivotide tetraxetan is a targeted radiopharmaceutical used for treating somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It consists of lutetium-177, a radioactive isotope, bound to vipivotide tetraxetan, a peptide that specifically targets somatostatin receptors on tumor cells. When administered, it selectively delivers radiation to these cells, minimizing damage to surrounding healthy tissue. This targeted approach makes it effective for treating GEP-NETs that have spread or cannot be surgically removed. Lutetium Lu 177 vipivotide tetraxetan is an important option in the arsenal of treatments for GEP-NETs, offering a targeted and precise therapeutic strategy.