For research use only. Not for therapeutic Use.
LX2343（Cat No.:I014455） is a multi-target reagent that shows promise in slowing down various pathological markers associated with Alzheimer’s disease. It acts as an inhibitor of β-secretase (BACE1) with an inhibitory concentration (IC50) of 11.43±0.36 μM. BACE1 plays a crucial role in the production of amyloid-beta peptides, which are known to contribute to the formation of plaques in the brain, a hallmark of Alzheimer’s disease. By inhibiting BACE1, LX2343 may help mitigate the progression of Alzheimer’s disease by reducing amyloid-beta production.
| Catalog Number | I014455 |
| CAS Number | 333745-53-2 |
| Synonyms | LX-2343; LX 2343; LX2343.;N-(benzo[d][1,3]dioxol-5-yl)-2-(N-(5-chloro-2-methoxyphenyl)phenylsulfonamido)acetamide |
| Molecular Formula | C22H19ClN2O6S |
| Purity | ≥95% |
| Target | PI3K/Akt/mTOR |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 2-[N-(benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide |
| InChI | InChI=1S/C22H19ClN2O6S/c1-29-19-9-7-15(23)11-18(19)25(32(27,28)17-5-3-2-4-6-17)13-22(26)24-16-8-10-20-21(12-16)31-14-30-20/h2-12H,13-14H2,1H3,(H,24,26) |
| InChIKey | ZGYSGIYKAVUVOR-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)Cl)N(CC(=O)NC2=CC3=C(C=C2)OCO3)S(=O)(=O)C4=CC=CC=C4 |
| Reference | </br>1: Sun G, Wang J, Guo X, Lei M, Zhang Y, Wang X, Shen X, Hu L. Design, synthesis </br> and biological evaluation of LX2343 derivatives as neuroprotective agents for the</br> treatment of Alzheimer’s disease. Eur J Med Chem. 2018 Feb 10;145:622-633. doi:</br> 10.1016/j.ejmech.2017.12.080. Epub 2018 Jan 2. PubMed PMID: 29339255.</br>2: Guo XD, Sun GL, Zhou TT, Wang YY, Xu X, Shi XF, Zhu ZY, Rukachaisirikul V, Hu </br> LH, Shen X. LX2343 alleviates cognitive impairments in AD model rats by</br> inhibiting oxidative stress-induced neuronal apoptosis and tauopathy. Acta</br> Pharmacol Sin. 2017 Aug;38(8):1104-1119. doi: 10.1038/aps.2016.128. Epub 2017 Jun</br> 26. PubMed PMID: 28649128; PubMed Central PMCID: PMC5547549.</br>3: Guo XD, Sun GL, Zhou TT, Xu X, Zhu ZY, Rukachaisirikul V, Hu LH, Shen X. Small</br> molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both</br> amyloid β production and clearance. Acta Pharmacol Sin. 2016</br> Sep;37(10):1281-1297. doi: 10.1038/aps.2016.80. Epub 2016 Aug 29. PubMed PMID:</br> 27569389; PubMed Central PMCID: PMC5057240.</br> </br> |
