For research use only. Not for therapeutic Use.
LXE408（Cat No.:I031194）is an emerging anti-parasitic agent developed for targeting Leishmania parasites, responsible for the neglected tropical disease leishmaniasis. It works by inhibiting crucial pathways within the parasite, disrupting its survival and replication. LXE408 demonstrates strong efficacy against Leishmania species, including drug-resistant strains, and offers a promising alternative to traditional treatments that often present toxicity and resistance issues. Its specificity and novel mechanism make LXE408 a focal point in research for safer, more effective therapies against leishmaniasis, contributing to efforts in global health and infectious disease management.
| Catalog Number | I031194 |
| CAS Number | 1799330-15-6 |
| Synonyms | LXE408; LXE 408; LXE-408 |
| Molecular Formula | C23H18FN7O2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| IUPAC Name | N-[4-fluoro-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide |
| InChI | InChI=1S/C23H18FN7O2/c1-12-5-4-8-25-19(12)15-10-26-23-29-21(30-31(23)11-15)17-9-16(6-7-18(17)24)28-22(32)20-13(2)27-14(3)33-20/h4-11H,1-3H3,(H,28,32) |
| InChIKey | GNVVPYCWVLCWKV-UHFFFAOYSA-N |
| SMILES | CC1=C(N=CC=C1)C2=CN3C(=NC(=N3)C4=C(C=CC(=C4)NC(=O)C5=C(N=C(O5)C)C)F)N=C2 |
| Reference | 1: Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. J Med Chem. 2020 Jul 29. doi: 10.1021/acs.jmedchem.0c00499. Epub ahead of print. PMID: 32667203. |
