For research use only. Not for therapeutic Use.
LY 134046 is a centrally active inhibitor of phenylethanolamine-N-methyltransferase (PNMT).
| Catalog Number | I007753 |
| CAS Number | 71274-97-0 |
| Synonyms | LY 134046; LY134046; LY-134046; Lilly 134046.;8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride |
| Molecular Formula | C10H11Cl2N |
| Purity | ≥95% |
| Target | PNMT Inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine |
| InChI | InChI=1S/C10H11Cl2N/c11-9-4-3-7-2-1-5-13-6-8(7)10(9)12/h3-4,13H,1-2,5-6H2 |
| InChIKey | IADAQXMUWITWNG-UHFFFAOYSA-N |
| SMILES | C1CC2=C(CNC1)C(=C(C=C2)Cl)Cl |
| Reference | </br>1:Behavioral effects of the inhibitors of phenylethanolamine-N-methyltransferase, LY 78335 and LY 134046, and their interactions with ethanol. Durcan MJ, Lister RG, Linnoila M.Psychopharmacology (Berl). 1990;101(2):196-202. PMID: 2349361 </br>2:Reduction of central epinephrine concentrations is consistent with the continued occurrence of ovulation in rats treated with an inhibitor (LY 134046) of phenylethanolamine N-methyltransferase. Sheaves R, Laynes R, MacKinnon P.Neuroendocrinology. 1985 Nov;41(5):432-6. PMID: 3903538 |
