LY 134046

• CAT Number: I007753
• CAS Number: 71274-97-0
• Molecular Formula: C10H11Cl2N
• Molecular Weight: 216.10
• Purity: ≥95%
• Synonyms: LY 134046; LY134046; LY-134046; Lilly 134046.;8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride
• Target: PNMT Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
• InChI: InChI=1S/C10H11Cl2N/c11-9-4-3-7-2-1-5-13-6-8(7)10(9)12/h3-4,13H,1-2,5-6H2
• InChIKey: IADAQXMUWITWNG-UHFFFAOYSA-N
• SMILES: C1CC2=C(CNC1)C(=C(C=C2)Cl)Cl

LY 134046(CAT: I007753) is a centrally active and selective inhibitor of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for converting norepinephrine to epinephrine in the adrenal medulla and central nervous system. By inhibiting PNMT, LY 134046 modulates catecholamine biosynthesis, making it a valuable tool in neuropharmacology research. It is particularly useful for studying the role of epinephrine in stress responses, cardiovascular regulation, and neurological disorders. LY 134046 aids in exploring therapeutic strategies for conditions such as hypertension, anxiety, and other stress-related disorders, providing insights into the regulation of adrenergic signaling pathways.