For research use only. Not for therapeutic Use.
LY235959 (Cat.No:I007799) is a selective and potent antagonist of the NMDA (N-methyl-D-aspartate) receptor subtype 2B (NR2B). It is a small molecule compound that has been extensively studied for its potential use in the treatment of various neurological disorders, including Alzheimer’s disease and neuropathic pain. LY235959 works by blocking the activity of NR2B receptors, which are involved in excitatory neurotransmission. This inhibition can help regulate synaptic plasticity and prevent excessive neuronal activation, thereby reducing neuronal damage and symptoms associated with certain neurological conditions.
| Catalog Number | I007799 |
| CAS Number | 137433-06-8 |
| Synonyms | LY 235959; LY235959; LY-235959.;3-Isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3S-(3alpha,4aalpha,6beta,8aalpha))- |
| Molecular Formula | C11H20NO5P |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Storage | Desiccate at +4C |
| IUPAC Name | (3S,4aR,6S,8aR)-6-(phosphonomethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid |
| InChI | InChI=1S/C11H20NO5P/c13-11(14)10-4-9-3-7(6-18(15,16)17)1-2-8(9)5-12-10/h7-10,12H,1-6H2,(H,13,14)(H2,15,16,17)/t7-,8-,9+,10-/m0/s1 |
| InChIKey | STIRHCNEGQQBOY-QEYWKRMJSA-N |
| SMILES | C1CC2CNC(CC2CC1CP(=O)(O)O)C(=O)O |
| Reference | </br>1:An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2). Rawls SM, Gomez T, Raffa RB.Pharmacol Biochem Behav. 2007 Mar;86(3):499-504. Epub 2007 Jan 20. PMID: 17306870 </br>2:Anticonvulsant and adverse effects of MK-801, LY 235959, and GYKI 52466 in combination with Ca2+ channel inhibitors in mice. Gasior M, Borowicz K, Kleinrok Z, Starownik R, Czuczwar SJ.Pharmacol Biochem Behav. 1997 Apr;56(4):629-35. PMID: 9130287 </br>3:Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor. Bhargava HN.Gen Pharmacol. 1997 Jan;28(1):61-4. PMID: 9112078 </br>4:Competitive NMDA-receptor antagonists, LY 235959 and LY 233053, enhance the protective efficacy of various antiepileptic drugs against maximal electroshock-induced seizures in mice. Borowicz KK, Gasior M, Kleinrok Z, Czuczwar SJ.Epilepsia. 1996 Jul;37(7):618-24. PMID: 8681893 |
