For research use only. Not for therapeutic Use.
Potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) for the treatment of osteoarthritis joint pain.
KEYWORDS: LY 2955303 dihydrochloride | supplier | RARγ antagonist | LY2955303 diHCl | LY-2955303 dihydrochloride | CAS [N.A.] | [1433497-19-8] | Retinoic Acid | Retinoic Acid (RAR) | Nuclear receptors | NR1B | osteoarthritis | pain | Antagonist | Receptors
Catalog Number | I047620 |
CAS Number | 2469014-43-3 |
Molecular Formula | C36H42N4O3.2HCl |
Purity | ≥95% |
IUPAC Name | 4-[5-(3,5-ditert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyrazol-3-yl]benzoic acid;dihydrochloride |
InChI | InChI=1S/C36H42N4O3.2ClH/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39;;/h8-15,20-23H,16-19H2,1-7H3,(H,42,43);2*1H |
SMILES | CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C.Cl.Cl |
Reference | NE Hughes et al. Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-7. |