LY 2955303 dihydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I047620
  • CAS Number: 2469014-43-3
  • Molecular Formula: C36H42N4O3.2HCl
  • Molecular Weight: 651.67
  • Purity: ≥95%
Inquiry Now

Potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) for the treatment of osteoarthritis joint pain.
KEYWORDS: LY 2955303 dihydrochloride | supplier | RARγ antagonist | LY2955303 diHCl | LY-2955303 dihydrochloride | CAS [N.A.] | [1433497-19-8] | Retinoic Acid | Retinoic Acid (RAR) | Nuclear receptors | NR1B | osteoarthritis | pain | Antagonist | Receptors


Catalog Number I047620
CAS Number 2469014-43-3
Molecular Formula C36H42N4O3.2HCl
Purity ≥95%
IUPAC Name 4-[5-(3,5-ditert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyrazol-3-yl]benzoic acid;dihydrochloride
InChI InChI=1S/C36H42N4O3.2ClH/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39;;/h8-15,20-23H,16-19H2,1-7H3,(H,42,43);2*1H
SMILES CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C.Cl.Cl
Reference

NE Hughes et al. Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-7.

Request a Quote