LY-3177833

• CAT Number: I007837
• CAS Number: 1627696-51-8
• Molecular Formula: C16H12FN5O
• Molecular Weight: 309.30
• Purity: ≥95%
• Synonyms: LY-3177833; LY 3177833; LY3177833.;(3R)-3-(5-Fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one
• Target: CDC7 inhibitor
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (3R)-3-(5-fluoropyrimidin-4-yl)-3-methyl-6-(1H-pyrazol-4-yl)-2H-isoindol-1-one
• InChI: InChI=1S/C16H12FN5O/c1-16(14-13(17)7-18-8-19-14)12-3-2-9(10-5-20-21-6-10)4-11(12)15(23)22-16/h2-8H,1H3,(H,20,21)(H,22,23)/t16-/m1/s1
• InChIKey: KNLVLWZENYQYRT-MRXNPFEDSA-N
• SMILES: CC1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F

LY-3177833（Cat No.:I007837）is a selective and potent inhibitor of cyclin-dependent kinase 9 (CDK9), a key enzyme involved in regulating transcription and cell cycle progression by controlling RNA polymerase II-mediated transcription elongation. By inhibiting CDK9, LY-3177833 disrupts the transcription of anti-apoptotic proteins like MCL-1, leading to apoptosis in cancer cells, particularly in tumors with high transcriptional activity. It is under investigation for its potential in cancer therapy, especially in hematologic malignancies such as leukemia and lymphoma, where CDK9 plays a crucial role in promoting tumor cell survival.