For research use only. Not for therapeutic Use.
Selective 5-HT1F receptor agonist with Ki value to be 1.87 nM
| Catalog Number | I007844 |
| CAS Number | 199673-74-0 |
| Molecular Formula | C21H22FN3O.HCl |
| Purity | ≥95% |
| IUPAC Name | 4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide;hydrochloride |
| InChI | InChI=1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H |
| SMILES | CN1CCC(CC1)C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F.Cl |
| Reference | DS Dupuis et al. G-protein activation at 5-HT1A receptors by the 5-HT1F ligand LY-334,370 in guinea-pig brain sections and recombinant cell lines. Br. J. Pharmacol. 1998, 124(2), 283–90.
S Shepheard et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY-334,370. Cephalalgia 1999, 19(10), 851-858. |
