For research use only. Not for therapeutic Use.
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].
LY-3381916 (IDO1-IN-5) (up to 100 µM) shows no obvious agonism of aryl hydrocarbon receptor (AHR)[1].
| Catalog Number | I019511 |
| CAS Number | 2166616-75-5 |
| Synonyms | 4-fluoro-N-[(1R)-1-[1-(oxane-4-carbonyl)-2,3-dihydroindol-5-yl]ethyl]benzamide |
| Molecular Formula | C23H25FN2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H25FN2O3/c1-15(25-22(27)16-2-5-20(24)6-3-16)18-4-7-21-19(14-18)8-11-26(21)23(28)17-9-12-29-13-10-17/h2-7,14-15,17H,8-13H2,1H3,(H,25,27)/t15-/m1/s1 |
| InChIKey | NUBWFWVVKLRSHS-OAHLLOKOSA-N |
| SMILES | CC(C1=CC2=C(C=C1)N(CC2)C(=O)C3CCOCC3)NC(=O)C4=CC=C(C=C4)F |
| Reference | [1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13). |
