LY-402913

• CAT Number: I007853
• CAS Number: 334970-65-9
• Molecular Formula: C28H24ClN3O6
• Molecular Weight: 533.96
• Purity: ≥95%
• Synonyms: LY-402913; LY 402913; LY402913.;Benzeneacetamide, 3-(9-chloro-3-methyl-4-oxoisoxazolo(4,5-C)quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)-
• Target: MRP1 Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 2-[3-(9-chloro-3-methyl-4-oxo-[1,2]oxazolo[4,5-c]quinolin-5-yl)phenyl]-N-(3,4,5-trimethoxyphenyl)acetamide
• InChI: InChI=1S/C28H24ClN3O6/c1-15-24-27(38-31-15)25-19(29)9-6-10-20(25)32(28(24)34)18-8-5-7-16(11-18)12-23(33)30-17-13-21(35-2)26(37-4)22(14-17)36-3/h5-11,13-14H,12H2,1-4H3,(H,30,33)
• InChIKey: VHYMJFJCXJXINF-UHFFFAOYSA-N
• SMILES: CC1=NOC2=C1C(=O)N(C3=C2C(=CC=C3)Cl)C4=CC=CC(=C4)CC(=O)NC5=CC(=C(C(=C5)OC)OC)OC

LY-402913(CAT: I007853) is a novel and selective inhibitor of multidrug resistance protein 1 (MRP1), effectively reversing resistance to MRP1 substrates like doxorubicin in HeLa-T5 cells (EC₅₀ = 0.90 µM) without exhibiting inherent cytotoxicity. This compound demonstrates remarkable selectivity, being approximately 22-fold more selective against MRP1 compared to P-glycoprotein in HL60/Adr and HL60/Vinc cells. In vivo, LY-402913, when co-administered with the MRP1 substrate vincristine, significantly delays the growth of MRP1-overexpressing tumors. This unique mechanism makes it a valuable tool in cancer research, particularly for studying drug resistance mechanisms and developing combination therapies to overcome multidrug resistance in tumor cells.