LY 450139

• CAT Number: I007857
• CAS Number: 866488-53-1
• Molecular Formula: C19H27N3O4
• Molecular Weight: 361.44
• Purity: ≥95%
• Synonyms: LY 450139; LY450139; LY-450139.;(S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-yl)amino)-1-oxopropan-2-yl)butanamide
• Target: Gamma-secretase inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide
• InChI: InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1
• InChIKey: PKXWXXPNHIWQHW-RCBQFDQVSA-N
• SMILES: CC(C)C(C(=O)NC(C)C(=O)NC1C2=CC=CC=C2CCN(C1=O)C)O

LY 450139(CAT: I007857) is a potent gamma-secretase inhibitor, designed to modulate amyloid precursor protein (APP) processing by reducing the production of amyloid-beta (Aβ) peptides. By targeting gamma-secretase, a critical enzyme in the amyloidogenic pathway, LY 450139 holds promise for mitigating amyloid plaque accumulation—a hallmark of Alzheimer’s disease (AD). This compound has been extensively studied in preclinical and clinical research for its potential to slow AD progression. LY 450139 serves as a valuable tool for understanding the pathophysiology of Alzheimer’s and advancing therapeutic strategies aimed at modifying disease outcomes by targeting amyloid-related mechanisms.