For research use only. Not for therapeutic Use.
LY117018 TFA (Cat No.: I040025) is a selective estrogen receptor modulator (SERM) used in cancer and endocrine disease research. As an active metabolite of raloxifene, it exhibits estrogenic and anti-estrogenic effects depending on the target tissue, making it valuable for studying hormone-related diseases such as breast cancer and osteoporosis. The trifluoroacetate (TFA) salt enhances its solubility and stability for in vitro and in vivo applications. LY117018 TFA is widely used in drug discovery for developing novel estrogen receptor-targeted therapies.
| CAS Number | 2390041-98-0 |
| Synonyms | [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone;2,2,2-trifluoroacetic acid |
| Molecular Formula | C29H26F3NO6S |
| Purity | ≥95% |
| InChI | InChI=1S/C27H25NO4S.C2HF3O2/c29-20-7-3-19(4-8-20)27-25(23-12-9-21(30)17-24(23)33-27)26(31)18-5-10-22(11-6-18)32-16-15-28-13-1-2-14-28;3-2(4,5)1(6)7/h3-12,17,29-30H,1-2,13-16H2;(H,6,7) |
| InChIKey | LJDNVFAQGQPDEJ-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.C(=O)(C(F)(F)F)O |
| Reference | [1]. Dinda S, et al. Effects of LY117018 (a SERM analog of raloxifene) on tumor suppressor proteins and proliferation of breast cancer cells.Horm Mol Biol Clin Investig. 2010 Aug 1;2(1):211-7. [2]. Baumann KH, et al. Effects of celecoxib and ly117018 combination on human breast cancer cells in vitro.Breast Cancer (Auckl). 2009 Apr 7;3:23-34. [3]. Yu J, et al.Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway.Eur J Pharmacol. 2008 Jul 28;589(1-3):32-6. |
