For research use only. Not for therapeutic Use.
LY177206(Cat No.:I031201)is a selective antagonist of the neurokinin-1 (NK1) receptor, a receptor involved in the transmission of pain and inflammation through the substance P neuropeptide. By blocking this receptor, LY177206 has been studied for its potential to reduce pain and inflammation, making it a candidate for treating conditions such as chronic pain, migraines, and anxiety disorders. It has also shown promise in preventing nausea and vomiting associated with chemotherapy. Though it has demonstrated efficacy in preclinical and early clinical trials, further research is needed to fully establish its therapeutic potential and safety profile.
Catalog Number | I031201 |
CAS Number | 127026-22-6 |
Synonyms | LY177206; LY-177206; LY 177206 |
Molecular Formula | C15H15NO |
Purity | 98% |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
IUPAC Name | 1-(2-methylbutan-2-yl)-3-oxoindene-2-carbonitrile |
InChI | InChI=1S/C15H15NO/c1-4-15(2,3)13-10-7-5-6-8-11(10)14(17)12(13)9-16/h5-8H,4H2,1-3H3 |
InChIKey | WWXYVYUCPQOVAM-UHFFFAOYSA-N |
SMILES | CCC(C)(C)C1=C(C(=O)C2=CC=CC=C21)C#N |