For research use only. Not for therapeutic Use.
LY2183240（Cat No.:I005269）is a selective inhibitor of endocannabinoid transport and degradation, enhancing levels of endogenous cannabinoids like anandamide by inhibiting their cellular uptake and hydrolysis. Primarily researched for its impact on the endocannabinoid system, LY2183240 has shown promise in studies related to pain management, mood regulation, and neuroprotection. By preventing the breakdown of endocannabinoids, it offers potential therapeutic applications for conditions such as chronic pain, inflammation, and anxiety. LY2183240 is valuable in exploring the therapeutic modulation of endocannabinoid pathways and advancing cannabinoid-based pharmacology.
| Catalog Number | I005269 |
| CAS Number | 874902-19-9 |
| Synonyms | N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide |
| Molecular Formula | C17H17N5O |
| Purity | ≥95% |
| Target | FAAH |
| Solubility | DMSO >10 mg/mL |
| Storage | Store at -20°C |
| IC50 | 270 pM (anandamide uptake); 12.4 nM (FAAH) |
| IUPAC Name | N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide |
| InChI | InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3 |
| InChIKey | GZNIYOXWFCDBBJ-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)N1C(=NN=N1)CC2=CC=C(C=C2)C3=CC=CC=C3 |
| Reference | </br>1:Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Powers MS, Barrenha GD, Mlinac NS, Barker EL, Chester JA.Psychopharmacology (Berl). 2010 Dec;212(4):571-83. doi: 10.1007/s00213-010-1997-2. Epub 2010 Sep 14. PMID: 20838777 Free PMC Article</br>2:The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Alexander JP, Cravatt BF.J Am Chem Soc. 2006 Aug 2;128(30):9699-704. PMID: 16866524 |
