For research use only. Not for therapeutic Use.
LY231617 is a potent and blood-brain barrier penetrable antioxidant. LY231617 is a neuroprotective agent in brain, it can be used for the research of nervous disease[1][2].
LY231617 (0.25, 1, 5, 10, and 25 μM; overnight) attenuates H2O2 toxicity to hippocampal cultures and shows the best effect at a concertration of 10 μM[1].
LY231617 (5 μM; overnight) attenuates 8-isoprostane production and glutathione depletion[1].
LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2].
LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2].
| Catalog Number | R036121 |
| CAS Number | 141545-89-3 |
| Synonyms | 2,6-ditert-butyl-4-(ethylaminomethyl)phenol;hydrochloride |
| Molecular Formula | C17H30ClNO |
| Purity | ≥95% |
| InChI | InChI=1S/C17H29NO.ClH/c1-8-18-11-12-9-13(16(2,3)4)15(19)14(10-12)17(5,6)7;/h9-10,18-19H,8,11H2,1-7H3;1H |
| InChIKey | SIWZKGFBUXQFDK-UHFFFAOYSA-N |
| SMILES | CCNCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C.Cl |
| Reference | [1]. Fuson KS, et al. Characterization of LY231617 protection against hydrogen peroxide toxicity. J Neurochem. 1999 Mar;72(3):1154-60. [2]. Clemens JA, et al. The antioxidant LY231617 reduces global ischemic neuronal injury in rats. Stroke. 1993 May;24(5):716-22; discussion 722-3. |
