LY2365109 hydrochloride

• CAT Number: I002309
• CAS Number: 1779796-27-8
• Molecular Formula: C22H28ClNO5
• Molecular Weight: 421.91
• Purity: ≥95%
• Target: target: GlyT1
• Solubility: DMSO ≥ 31 mg/mL
• Storage: 2-8°C
• IUPAC Name: 2-[2-[4-(1,3-benzodioxol-5-yl)-2-tert-butylphenoxy]ethyl-methylamino]acetic acid;hydrochloride
• InChI: InChI=1S/C22H27NO5.ClH/c1-22(2,3)17-11-15(16-6-8-19-20(12-16)28-14-27-19)5-7-18(17)26-10-9-23(4)13-21(24)25;/h5-8,11-12H,9-10,13-14H2,1-4H3,(H,24,25);1H
• InChIKey: ZQVOAGQZHDAFRM-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=C(C=CC(=C1)C2=CC3=C(C=C2)OCO3)OCCN(C)CC(=O)O.Cl

LY2365109 hydrochloride（Cat No.:I002309） is a potent and selective GlyT1 inhibitor with an IC50 of 15.8 nM for inhibiting glutamate uptake by hGlyT1-overexpressing cells.

Reference

[1]. Perry KW et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas. Neuropharmacology. 2008 Oct;55(5):743-54.

[2]. Shen HY et al. Glycine transporter 1 is a target for the treatment of epilepsy. Neuropharmacology. 2015 Dec;99:554-65.