LY2606368 dihydrochloride

• CAT Number: I000927
• CAS Number: 1234015-54-3
• Molecular Formula: C18H21Cl2N7O2
• Molecular Weight: 438.31
• Purity: ≥95%
• Target: Checkpoint Kinase (Chk); Apoptosis
• Solubility: DMSO: ≥ 32 mg/mL
• Storage: Store at -20C
• IC50: 1.5 nM (SW1990 cell line) [1]
• IUPAC Name: 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile;dihydrochloride
• InChI: InChI=1S/C18H19N7O2.2ClH/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;;/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);2*1H
• InChIKey: KMEIPKXRCJTZBZ-UHFFFAOYSA-N
• SMILES: COC1=C(C(=CC=C1)OCCCN)C2=CC(=NN2)NC3=NC=C(N=C3)C#N.Cl.Cl

LY2606368 dihydrochloride（Cat No.:I000927）is a potent and selective inhibitor of checkpoint kinase 1 (Chk1), a key regulator of the DNA damage response. By inhibiting Chk1, LY2606368 prevents the repair of DNA damage, leading to cell cycle arrest and apoptosis, particularly in cancer cells with high levels of replication stress. It enhances the efficacy of DNA-damaging agents, such as chemotherapy and radiation, by sensitizing tumor cells to these treatments. LY2606368 is widely used in cancer research to explore novel therapeutic strategies for targeting DNA repair mechanisms in aggressive cancers.

Reference

[1]. Wenjuan Wu, et al. Abstract 1776: Antitumor activity of Chk1 inhibitor LY2606368 as a single agent in SW1990 human pancreas orthotopic tumor model. Cancer Res April 15, 2012; 72(8 Supplement): 1776