For research use only. Not for therapeutic Use.
LY2835219 free base(Cat No.:I000911), also known as Abemaciclib, is a potent and selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). By inhibiting these kinases, it prevents phosphorylation of the retinoblastoma protein (Rb), leading to cell cycle arrest in the G1 phase. This mechanism makes it highly effective in targeting cancers driven by dysregulated CDK4/6 activity, particularly hormone receptor-positive breast cancer. LY2835219 is used in cancer research and therapy to inhibit tumor growth and is often administered in combination with hormonal therapies for improved efficacy.
Catalog Number | I000911 |
CAS Number | 1231929-97-7 |
Synonyms | N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine |
Molecular Formula | C27H32F2N8 |
Purity | ≥95% |
Target | CDK |
Solubility | 10 mM in DMSO |
Storage | Store at -20°C |
IC50 | 2 nM(CDK4); 10 nM(CDK6) |
IUPAC Name | N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine |
InChI | InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) |
InChIKey | UZWDCWONPYILKI-UHFFFAOYSA-N |
SMILES | CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F |
Reference | <p style=/line-height:25px/> |