For research use only. Not for therapeutic Use.
LY285434（Cat No.:I013323）is a selective inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a key role in converting inactive cortisone to active cortisol in tissues. By inhibiting 11β-HSD1, LY285434 aims to reduce excessive local cortisol levels, which are associated with conditions such as metabolic syndrome, obesity, and insulin resistance. This inhibition may also help modulate inflammation and improve metabolic function. LY285434 has been investigated as a potential treatment for disorders related to dysregulated cortisol metabolism, though further clinical trials are required to assess its safety, efficacy, and long-term outcomes.
| Catalog Number | I013323 |
| CAS Number | 159748-08-0 |
| Molecular Formula | C₂₃H₂₅N₅O₂ |
| Purity | ≥95% |
| Target | Angiotensin Receptor |
| Solubility | DMSO |
| IUPAC Name | 2-[5-[2-(2H-tetrazol-5-yl)phenyl]indol-1-yl]octanoic acid |
| InChI | InChI=1S/C23H25N5O2/c1-2-3-4-5-10-21(23(29)30)28-14-13-17-15-16(11-12-20(17)28)18-8-6-7-9-19(18)22-24-26-27-25-22/h6-9,11-15,21H,2-5,10H2,1H3,(H,29,30)(H,24,25,26,27) |
| InChIKey | FCWWQZQDBUMEJF-UHFFFAOYSA-N |
| SMILES | CCCCCCC(C(=O)O)N1C=CC2=C1C=CC(=C2)C3=CC=CC=C3C4=NNN=N4 |
