For research use only. Not for therapeutic Use.
LY2857785（Cat No.:I002076） is a reversible ATP-competitive inhibitor that targets cyclin-dependent kinases (CDKs) including CDK9, CDK8, and CDK7. It exhibits potent inhibitory activity with IC50 values of 11 nM, 16 nM, and 246 nM for CDK9, CDK8, and CDK7, respectively. By binding to the ATP-binding site of these kinases, LY2857785 interferes with their activity and disrupts cell cycle progression and transcriptional regulation. This compound holds potential as a therapeutic agent in cancer treatment, as CDKs play critical roles in cell growth and proliferation.
| Catalog Number | I002076 |
| CAS Number | 1619903-54-6 |
| Synonyms | (1r,4r)-N1-(4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)-N4-(tetrahydro-2H-pyran-4-yl)cyclohexane-1,4-diamine |
| Molecular Formula | C26H36N6O |
| Purity | ≥95% |
| Target | Cyclin-Dependent Kinases |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C(protect from light) |
| IUPAC Name | 4-N-[4-(2-methyl-3-propan-2-ylindazol-5-yl)pyrimidin-2-yl]-1-N-(oxan-4-yl)cyclohexane-1,4-diamine |
| InChI | InChI=1S/C26H36N6O/c1-17(2)25-22-16-18(4-9-24(22)31-32(25)3)23-10-13-27-26(30-23)29-20-7-5-19(6-8-20)28-21-11-14-33-15-12-21/h4,9-10,13,16-17,19-21,28H,5-8,11-12,14-15H2,1-3H3,(H,27,29,30) |
| InChIKey | LHIUZPIDLZYPRL-UHFFFAOYSA-N |
| SMILES | CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3)NC4CCC(CC4)NC5CCOCC5 |
| Reference | <p style=/line-height:25px/> |
