For research use only. Not for therapeutic Use.
LY2940094（Cat No.:I019327）, is a selective inhibitor of phosphoinositide 3-kinase (PI3K) α and δ isoforms. It binds to the p110α and p110δ subunits of PI3K, blocking their activity. This compound has demonstrated potent antiproliferative effects in cancer cells that rely on PI3K signaling. Preclinical studies have shown its potential in treating various cancers, including breast, ovarian, and lung cancer.
| Catalog Number | I019327 |
| CAS Number | 1307245-86-8 |
| Molecular Formula | C₂₂H₂₃ClF₂N₄O₂S |
| Purity | ≥95% |
| Target | Opioid Receptor |
| Storage | Store at -20°C |
| IUPAC Name | [2-[4-[(2-chloro-4,4-difluorospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methylpyrazol-1-yl]pyridin-3-yl]methanol |
| InChI | InChI=1S/C22H23ClF2N4O2S/c1-14-16(11-29(27-14)20-15(12-30)3-2-6-26-20)10-28-7-4-21(5-8-28)19-17(9-18(23)32-19)22(24,25)13-31-21/h2-3,6,9,11,30H,4-5,7-8,10,12-13H2,1H3 |
| InChIKey | NKQHBJNRBKHUQR-UHFFFAOYSA-N |
| SMILES | CC1=NN(C=C1CN2CCC3(CC2)C4=C(C=C(S4)Cl)C(CO3)(F)F)C5=C(C=CC=N5)CO |
| Reference | [1]. Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. |
