For research use only. Not for therapeutic Use.
LY2955303（Cat No.:I007826）is a selective inhibitor of fatty acid amide hydrolase (FAAH), an enzyme responsible for breaking down endocannabinoids, such as anandamide, in the central nervous system. By inhibiting FAAH, LY2955303 enhances endocannabinoid signaling, potentially offering therapeutic effects in pain management, anxiety reduction, and neuroinflammatory disorders. This compound has been explored in preclinical and clinical settings, showing promise in modulating the endocannabinoid system for therapeutic benefit. LY2955303’s mechanism positions it as a candidate for addressing pain, mood disorders, and inflammation by supporting elevated levels of endogenous cannabinoids.
| Catalog Number | I007826 |
| CAS Number | 1433497-19-8 |
| Synonyms | LY2955303; LY-2955303; LY 2955303.;4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid |
| Molecular Formula | C36H42N4O3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 2-8°C |
| IUPAC Name | 4-[5-(3,5-ditert-butylphenyl)-1-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyrazol-3-yl]benzoic acid |
| InChI | InChI=1S/C36H42N4O3/c1-35(2,3)28-20-27(21-29(22-28)36(4,5)6)32-23-31(24-8-10-26(11-9-24)34(42)43)37-40(32)30-14-12-25(13-15-30)33(41)39-18-16-38(7)17-19-39/h8-15,20-23H,16-19H2,1-7H3,(H,42,43) |
| InChIKey | YVXYHNKIOFSFMZ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=CC(=C1)C2=CC(=NN2C3=CC=C(C=C3)C(=O)N4CCN(CC4)C)C5=CC=C(C=C5)C(=O)O)C(C)(C)C |
| Reference | </br>Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design In Press, Accepted Manuscript, Available online 20 May 2016 Norman E. Hughes, Thomas J. Bleisch, Scott A. Jones, Timothy I. Richardson, Robert A. Doti, Yong Wang, Stephanie L. Stout, Gregory L. Durst, Mark G. Chambers, Jennifer L. Oskins, Chaohua Lin, Lisa A. Adams, Todd J. Page, Robert J. Barr, Richard W. Zink, Harold Osborne, Chahrzad Montrose-Rafizadeh, Bryan H. Norman |
