For research use only. Not for therapeutic Use.
LY3295668（Cat No.:I031229）is a selective and potent inhibitor of Aurora A kinase, an enzyme crucial for regulating cell division and mitosis. By inhibiting Aurora A kinase, LY3295668 disrupts the proper alignment and segregation of chromosomes during cell division, leading to apoptosis, particularly in cancer cells. It is being investigated for its potential in cancer therapy, especially in tumors where Aurora A kinase is overexpressed, such as certain types of breast, lung, and ovarian cancers. LY3295668 holds promise in oncology research as a targeted therapeutic agent for tumor growth suppression.
| Catalog Number | I031229 |
| CAS Number | 1919888-06-4 |
| Synonyms | LY3295668, LY-3295668, LY 3295668; AK-01; AK 01; AK01; |
| Molecular Formula | C24H26ClF2N5O2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl]methyl]-2-methylpiperidine-4-carboxylic acid |
| InChI | InChI=1S/C24H26ClF2N5O2/c1-14-10-21(31-30-14)29-20-7-6-18(26)19(28-20)12-24(23(33)34)8-9-32(15(2)11-24)13-16-4-3-5-17(25)22(16)27/h3-7,10,15H,8-9,11-13H2,1-2H3,(H,33,34)(H2,28,29,30,31)/t15-,24-/m1/s1 |
| InChIKey | YQQZZYYQTCPEAS-OYLFLEFRSA-N |
| SMILES | C[C@@H]1C[C@](CCN1CC2=C(C(=CC=C2)Cl)F)(CC3=C(C=CC(=N3)NC4=NNC(=C4)C)F)C(=O)O |
| Reference | 1: Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K, Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH, Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C, Campbell RM, Henry JR, Buchanan SG. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469. doi: 10.1158/2159-8290.CD-18-0469. [Epub ahead of print] PubMed PMID: 30373917. |
