For research use only. Not for therapeutic Use.
LY389795 (Cat No.: I007849) is a selective and potent agonist of the metabotropic glutamate receptor 2 (mGluR2), developed for potential use in treating neurological and psychiatric disorders. By modulating glutamatergic neurotransmission, LY389795 may help regulate excitatory signaling in the brain, showing promise in conditions like anxiety, depression, and schizophrenia. It has been evaluated in preclinical models for its anxiolytic and antipsychotic-like effects. LY389795 is a valuable tool in neuroscience research for exploring mGluR2 function and its therapeutic potential in central nervous system disorders.
| CAS Number | 222529-89-7 |
| Synonyms | LY389795; LY 389795; LY-389795.;(4S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Molecular Formula | C7H9NO4S |
| Purity | ≥95% |
| Target | mGlu2/3 Receptor Agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| InChI | InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 |
| InChIKey | QBHIOYZCUZBIEN-MDASVERJSA-N |
| SMILES | C1C(C2C(C2S1)C(=O)O)(C(=O)O)N |
| Reference | </br>1:Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Jones CK, Eberle EL, Peters SC, Monn JA, Shannon HE.Neuropharmacology. 2005;49 Suppl 1:206-18. PMID: 15998527 </br>2:Anti-epileptic activity of group II metabotropic glutamate receptor agonists (–)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (–)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS.Neuropharmacology. 2001 Jul;41(1):8-18. PMID: 11445181 </br>3:Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. Kingston AE, O/’Neill MJ, Lam A, Bales KR, Monn JA, Schoepp DD.Eur J Pharmacol. 1999 Jul 21;377(2-3):155-65. PMID: 10456425 |
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