For research use only. Not for therapeutic Use.
LY389795 is a group II (mGlu2/3) metabotropic glutamate receptor agonist which is used in inflammatory pain models.
| Catalog Number | I007849 |
| CAS Number | 222529-89-7 |
| Synonyms | LY389795; LY 389795; LY-389795.;(4S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| Molecular Formula | C7H9NO4S |
| Purity | ≥95% |
| Target | mGlu2/3 Receptor Agonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | (1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid |
| InChI | InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1 |
| InChIKey | QBHIOYZCUZBIEN-MDASVERJSA-N |
| SMILES | C1C(C2C(C2S1)C(=O)O)(C(=O)O)N |
| Reference | </br>1:Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing. Jones CK, Eberle EL, Peters SC, Monn JA, Shannon HE.Neuropharmacology. 2005;49 Suppl 1:206-18. PMID: 15998527 </br>2:Anti-epileptic activity of group II metabotropic glutamate receptor agonists (–)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (–)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795). Moldrich RX, Jeffrey M, Talebi A, Beart PM, Chapman AG, Meldrum BS.Neuropharmacology. 2001 Jul;41(1):8-18. PMID: 11445181 </br>3:Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. Kingston AE, O/’Neill MJ, Lam A, Bales KR, Monn JA, Schoepp DD.Eur J Pharmacol. 1999 Jul 21;377(2-3):155-65. PMID: 10456425 |
