For research use only. Not for therapeutic Use.
LY43578(CAT: I007856) is an orally active aromatase inhibitor that demonstrates potent inhibition of cytochrome P450-dependent enzymatic activities. In rat hepatic microsomes, LY43578 effectively inhibits p-nitroanisole O-demethylation and ethylmorphine N-demethylation, with IC50 values of 0.3 μM and 5 μM, respectively. By modulating P450 enzyme activity, LY43578 serves as a valuable tool in the investigation of steroid metabolism and endocrine regulation. Its oral bioavailability and pharmacological profile also support its application in neurological disorder research, where aromatase and estrogen synthesis play critical roles. LY43578 is a versatile compound for studies in neuropharmacology, endocrinology, and metabolic regulation.
| CAS Number | 26766-35-8 |
| Synonyms | bis(4-chlorophenyl)-pyrimidin-5-ylmethanol |
| Molecular Formula | C17H12Cl2N2O |
| Purity | ≥95% |
| IUPAC Name | bis(4-chlorophenyl)-pyrimidin-5-ylmethanol |
| InChI | InChI=1S/C17H12Cl2N2O/c18-15-5-1-12(2-6-15)17(22,14-9-20-11-21-10-14)13-3-7-16(19)8-4-13/h1-11,22H |
| InChIKey | CSRYTZCLFTYZLS-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C3=CN=CN=C3)O)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
