For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>LY451395(Mibampator) is a potent and highly selective potentiator of the AMPA receptors.<br>IC50 value:<br>Target: AMPA receptor potentiator<br>in vitro:<br>in vivo: Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and LY451395 reverses the central effects of an acutely intoxicating dose of ethanol in the rat. LY451395 significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].</p>
| Catalog Number | I003378 |
| CAS Number | 375345-95-2 |
| Molecular Formula | C21H30N2O4S2 |
| Purity | ≥95% |
| Target | AMPAR |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| InChI | InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1 |
| InChIKey | ULRDYYKSPCRXAJ-KRWDZBQOSA-N |
| SMILES | CC(S(=O)(NC[C@@H](C1=CC=C(C2=CC=C(CCNS(=O)(C)=O)C=C2)C=C1)C)=O)C |
| Reference | </br>1:Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer/’s disease. Trzepacz PT, Cummings J, Konechnik T, Forrester TD, Chang C, Dennehy EB, Willis BA, Shuler C, Tabas LB, Lyketsos C.Int Psychogeriatr. 2013 May;25(5):707-19. doi: 10.1017/S1041610212002141. Epub 2012 Dec 21. PMID: 23257314 Free PMC Article</br>2:Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects. Jhee SS, Chappell AS, Zarotsky V, Moran SV, Rosenthal M, Kim E, Chalon S, Toublanc N, Brandt J, Coutant DE, Ereshefsky L.J Clin Pharmacol. 2006 Apr;46(4):424-32. PMID: 16554450 |
