LY451395

• CAT Number: I003378
• CAS Number: 375345-95-2
• Molecular Formula: C21H30N2O4S2
• Molecular Weight: 438.60
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: N-[(2R)-2-[4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenyl]propyl]propane-2-sulfonamide
• InChI: InChI=1S/C21H30N2O4S2/c1-16(2)29(26,27)23-15-17(3)19-9-11-21(12-10-19)20-7-5-18(6-8-20)13-14-22-28(4,24)25/h5-12,16-17,22-23H,13-15H2,1-4H3/t17-/m0/s1
• InChIKey: ULRDYYKSPCRXAJ-KRWDZBQOSA-N
• SMILES: C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)C2=CC=C(C=C2)CCNS(=O)(=O)C

LY451395（Cat No.:I003378）is a selective and potent antagonist of the 5-HT2A serotonin receptor, which plays a key role in mood regulation, cognition, and sensory perception. By blocking this receptor, LY451395 has potential therapeutic applications in treating psychiatric disorders such as schizophrenia, anxiety, and depression. It may also help mitigate hallucinatory effects often associated with 5-HT2A activation. Preclinical studies suggest that LY451395 could have a more favorable side effect profile compared to other 5-HT2A antagonists, but further clinical trials are needed to confirm its safety, efficacy, and potential therapeutic benefits.